CGRI PUBLICATIONS
The Following Publications are the recent works of CGRI and our collaborators. Some of the publications are downloadable; while others are viewable on various journal/research directory websites.
PUBLICATION TITLE:
1. “Promoting the genomic revolution in Africa through the Nigerian 100K Genome Project.” Nat Genet , 2022 May;54(5):531-536
AUTHOR(S):
Segun Fatumo, Aminu Yakubu, Olubukunola Oyedele, Jumi Popoola, Delali Attiogbe Attipoe, Golibe Eze-Echesi, Fatima Z Modibbo, Nabila Ado-Wanka, 54gene Team, NCD-GHS Consortium, Omolola Salako, Oyekanmi Nashiru, Babatunde L Salako, Colm O’Dushlaine and Abasi Ene-Obong.
PUBLICATION TITLE:
2. Lipid traits and type 2 diabetes risk in African ancestry individuals: A Mendelian Randomization study” The lancet.com Vol 78 Month April, 2022
AUTHOR(S):
⦁ Opeyemi Soremekun,a Ville Karhunen,b,c Yiyan He,b Skanda Rajasundaram,d,e Bowen Liu,f Apostolos Gkatzionis,g,h Chisom Soremekun,a Brenda Udosen,a Hanan Musa,a Sarah Silva,a,u Christopher Kintu,a Richard Mayanja,a Mariam Nakabuye,a Tafadzwa Machipisa,i,j,k Amy Mason,f Marijana Vujkovic,l,m,n Verena Zuber,o Mahmoud Soliman,p Joseph Mugisha,q Oyekanmi Nash, Pontiano Kaleebu,q Moffat Nyirenda,q Tinashe Chikowore,s,t Dorothea Nitsch,u Stephen Burgess,f,v Dipender Gill,o,w and Segun Fatumo.
PUBLICATION TITLE:
3. “SARS-CoV-2 Omicron spike glycoprotein receptor binding domain exhibits super-binder ability with ACE2 but not convalescent monoclonal antibody”. Comput Biol Med. 2022 Mar;142:105226. doi: 10.1016/j.compbiomed.2022.105226. Epub 2022 Jan 7. PMID: 35066447 Free PMC article.
AUTHOR(S):
Omotuyi O, Olubiyi O, Nash O, Afolabi E, Oyinloye B, Fatumo S, Femi-Oyewo M, Bogoro S.
PUBLICATION TITLE:
4. “Strengthening Bioinformatics and Genomics Analyses Skills in Africa for Attainment of the Sustainable Development Goals: Report of the 2nd Conference of the Nigerian Bioinformatics and Genomics Network.” Am. J. Trop. Med. Hyg., 00(00), 2022, pp. 1–3
AUTHOR(S):
Itunuoluwa Isewon,1,2,3† Chisom Soremekun,4,5,6† Marion Adebiyi,1,2,3,7 Charles Adetunji,8 Adewale Joseph Ogunleye,9 Amos Oreniyi Bajeh,7 Emmanuel Oluwatobi Asani,7 Babatunde Gbadamosi,7 Opeyemi Soremekun,4 Brenda Udosen,4,6 Christopher Kintu,4,5 Roseline Ogundokun,7 Micheal Olaolu Arowolo,7 Opeyemi Matiluko,7 Oyekanmi Nashiru,6 Ezekiel Adebiyi,1,2,3,10 Chinwe Ekenna,11 and Segun Fatumo.
PUBLICATION TITLE:
5. “Microbiome Diversity Analysis of the Bacterial Community in Idah River, Kogi State, Nigeria.” Advances in Microbiology, 12, 343-362. doi: 10.4236/aim.2022.125025.
AUTHOR(S):
Adedire, D., Jimoh, A. , Kashim-Bello, Z. , Shuaibu, B. , Popoola, O. , Pate, K. , Uzor, O. , Etingwa, E. , Joda, J. , Opaleye, O. , Ogunlowo, V. , Adeniran, K. and Nashiru, O.
PUBLICATION TITLE:
6. “Assessment of the physicochemical qualities and microbiological profile of Idah River, Kogi State, Nigeria.” African Journal of Microbiology Research, 15(7), 377-387
AUTHOR(S):
Adedire, D. E., Jimoh, A. O., Kashim-Bello, Z., Shuaibu, B. A. W., Popoola, O. A., Pate, K. I., Uzor, O. S., Etingwa, E., Joda, J. F., Opaleye, O. O., Adeniran, K. R., Francis, E. E., Olukotun, G. B., & Nashiru, O.
PUBLICATION TITLE:
7. “In-silico analysis reveals ⦁ druggable⦁ single nucleotide polymorphisms in angiotensin 1 converting enzyme involved in the onset of blood pressure”.⦁ BMC Res Notes. 2021 Dec 20;14(1):457. doi: 10.1186/s13104-021-05879-z. PMID: 34930451 Free PMC article.
AUTHOR(S):
Udosen B, Soremekun O, Ekenna C, Idowu Omotuyi O, Chikowore T, Nashiru O, Fatumo S.
PUBLICATION TITLE:
8. “Discovery and fine-mapping of kidney function loci in first genome-wide association study in Africans” Hum Mol Genet. 2021 Jul 28;30(16):1559-1568. doi: 10.1093/hmg/ddab088. PMID: 33783510 Free PMC article.
AUTHOR(S):
Fatumo S, Chikowore T, Kalyesubula R, Nsubuga RN, Asiki G, Nashiru O, Seeley J, Crampin AC, Nitsch D, Smeeth L, Kaleebu P, Burgess S, Nyirenda M, Franceschini N, Morris AP, Tomlinson L, Newton R.
PUBLICATION TITLE:
9. “Genome-Wide Association and Mendelian Randomization Analysis Reveal the Causal Relationship Between White Blood Cell Subtypes and Asthma in Africans” Front Genet. 2021 Dec 2;12:749415. doi: 10.3389/fgene.2021.749415. eCollection 2021. PMID: 34925446 Free PMC article.
AUTHOR(S):
Soremekun O, Soremekun C, Machipisa T, Soliman M, Nashiru O, Chikowore T, Fatumo S.
PUBLICATION TITLE:
10. “Transcription-translation error: ⦁ In-silico⦁ investigation of the structural and functional impact of deleterious single nucleotide polymorphisms in ⦁ GULP1⦁ gene⦁ ”⦁ .⦁ Inform Med Unlocked. 2021;22:100503. doi: 10.1016/j.imu.2020.100503. Epub 2020 Dec 24. PMID: 33665355 Free PMC article.
AUTHOR(S):
Soremekun OS, Ezenwa C, Soliman M, Chikowore T, Nashiru O, Fatumo S.
PUBLICATION TITLE:
11. “Comparative analyses of copy number variations between Bos taurus and Bos indicus” .BMC Genomics. 2020 Oct 1;21(1):682. doi: 10.1186/s12864-020-07097-6. PMID: 33004001 Free PMC article.
AUTHOR(S):
Hu Y, Xia H, Li M, Xu C, Ye X, Su R, Zhang M, Nash O, Sonstegard TS, Yang L, Liu GE, Zhou Y.
PUBLICATION TITLE:
12. “Computational and drug target analysis of functional single nucleotide polymorphisms associated with ⦁ Haemoglobin⦁ Subunit Beta (HBB) gene⦁ ”⦁ .⦁ Comput Biol Med. 2020 Oct;125:104018. doi: 10.1016/j.compbiomed.2020.104018. Epub 2020 Sep 25. PMID: 33022520
AUTHOR(S):
Soremekun OS, Ezenwa C, Isewon I, Soliman M, Idowu O, Nashiru O, Fatumo S.
PUBLICATION TITLE:
13. “Atomistic simulation reveals structural mechanisms underlying D614G spike glycoprotein-enhanced fitness in SARS-COV-2” .J Comput Chem. 2020 Sep 15;41(24):2158-2161. doi: 10.1002/jcc.26383. Epub 2020 Jul 21. PMID: 32779780 Free PMC article.
AUTHOR(S):
Omotuyi IO, Nash O, Ajiboye OB, Iwegbulam CG, Oyinloye EB, Oyedeji OA, Kashim ZA, Okaiyeto K.
PUBLICATION TITLE:
14. “The Nigerian Bioinformatics and Genomics Network (NBGN): a collaborative platform to advance bioinformatics and genomics in Nigeria⦁ ”⦁ .⦁ Glob Health Epidemiol Genom. 2020 Jul 15;5:e3. doi: 10.1017/gheg.2020.3. eCollection 2020. PMID: 32742665 Free PMC article.
AUTHOR(S):
Fatumo S, Ebenezer TE, Ekenna C, Isewon I, Ahmad U, Adetunji C, Oladipo EK, Adebiyi M, Adebiyi E, Nashiru O; Nigerian Bioinformatics and Genomics Network.
PUBLICATION TITLE:
15. “Genetic loci implicated in meta-analysis of body shape in Africans⦁ ”⦁ Nutr Metab Cardiovasc Dis. 2022 Jun;32(6):1511-1518. doi: 10.1016/j.numecd.2022.03.010. Epub 2022 Mar 26. PMID: 35461751 Free article.
AUTHOR(S):
Nakabuye M, Kamiza AB, Soremekun O, Machipisa T, Cohen E, Pirie F, Nashiru O, Young E, Sandhu MS, Motala AA, Chikowore T, Fatumo S.
PUBLICATION TITLE:
16. “Aframomum melegueta secondary metabolites exhibit polypharmacology against SARS-CoV-2 drug targets: in vitro validation of furin inhibition Aframomum melegueta secondary metabolites exhibit polypharmacology against SARS-CoV-2 drug targets: in vitro validation of furin inhibition” Phytotherapy Research. 2020;1–12.
AUTHOR(S):
Olaposi Omotuyi, Oyekanmi Nash, Basiru O. Ajiboye, Victor O. Olumekun, Babatunji E. Oyinloye, Oludare T. Osuntokun, Adebisi Olonisakin, A. Olajide Ajayi. Olasehinde Olusanya, Funmilola S. Akomolafe, Niyi Adelakun.
PUBLICATION TITLE:
17. “Identification of differentially expressed genes present in the whole blood of Pulmonary Arterial Hypertension patients and control patients: An integrated bioinformatics approach.” Informatics in Medicine Unlocked 20 (2020) 100380
AUTHOR(S):
Chisom Ezenwa, Opeyemi S. Soremekun , Oyekanmi Nashiru and Segun Fatumo
PUBLICATION TITLE:
18. “The Disruption of SARS-CoV-2 RBD/ACE-2 Complex by Ubrogepant Is Mediated by Interface Hydration”. Preprints 2020, 2020030466 (doi: 10.20944/preprints202003.0466.v1) (31 March, 2020)
AUTHOR(S):
Omotuyi, O.; Nash, O.; Ajiboye, B.; Metibemu, D.; Oyinloye, B.; Ojo, A.; Okaiyeto, K.
PUBLICATION TITLE:
19. “Analysis of a Tropical Warm Spring Microbiota Using 16S rRNA Metabarcoding” Advances in Microbiology, 2020, 10, 145-165 April, 2020
AUTHOR(S):
Deborah Fasesan,, Karim Dawkins, Roberto Ramirez, Hadiza Rasheed-Jada, Abiodun Onilude, Oyekanmi Nash, Nwadiuto Esiobu.
PUBLICATION TITLE:
20. “Darunavir Disrupts Critical Nodes in Metastable 2019-nCoV-RBD/ACE-2 Complex”. Preprints 2020, 2020030125 (doi: 10.20944/preprints202003.0125.v1 {7 March, 2020)
AUTHOR(S):
Omotuyi, O.I.; Nash, O.; Ajiboye, B.O.; Metibemu, D.S.; Oyinloye, B.E.; Adelakun, N.S.; Hurdayal, R.; Aruleba, R.T.; Kappo, A.P.
PUBLICATION TITLE:
21. “The Sickle Cell Disease Ontology: enabling universal sickle cell-based knowledge representation”. Database, 2019, 1–12ining Initiative (AGMT): Show-casing a Community and Framework Driven Genomic Medicine Training for Nurses in Africa” Frontiers in Genetics, 2019 Nov (section ELSI in Science and Genetics Article type: Original Research Manuscript ID: 490241)
AUTHOR(S):
Sickle Cell Disease Ontology Working Group (Adijat Ozohu Jimoh, Zainab Abimbola Kashim)
PUBLICATION TITLE:
22. African Genomic Medicine Training Initiative. “The African Genomic Medicine Training Initiative (AGMT): Show-casing a Community and Framework Driven Genomic Medicine Training for Nurses in Africa” Frontiers in Genetics, 2019 Nov (section ELSI in Science and Genetics Article type: Original Research Manuscript ID: 490241)
AUTHOR(S):
Nicola Mulder, Victoria P. Nembaware, Oyekanmi Nash, Zainab Kashim, Esther Owoeye,
PUBLICATION TITLE:
23. ‘Membrane-bound Transcription Factor Site-1 Protease in PF429242 Bound State’: Computational Kinetics and Dynamics of Reversible Binding”. Drug Research ((Stuttg), 2019, Aug, DOI: 10.1055/a-0807-8640
AUTHOR(S):
Omotuyi I. Olaposi, Nash Oyekanmi, Ojo, A. Ayodeji, Eniafe, O. Gabriel
PUBLICATION TITLE:
24. Genome Sequence Analysis Reveals Selection Signatures in Endangered Trypano-tolerant West African Muturu Cattle. Front. Genet, 2019 Jun 4;10:442.
AUTHOR(S):
Abdulfatai Tijjani, Yuri Tani Utsunomiya, Arinze Ezekwe, Oyekanmi Nash, Olivier Hubert Hanotte.
PUBLICATION TITLE:
25. Complimentary methods for multivariate genome-wide association study identify new susceptibility genes for blood cell. Front Genet. 2019 Apr 26;10:334.
AUTHOR(S):
Segun A Fatumo, Tommy Carstensen, Oyekanmi Nashiru, Deepti Gurdasani, Manjinder Sandhu, Pontiano Kaleebu.
PUBLICATION TITLE:
26. T-705-modified ssRNA in complex with Lassa Virus Nucleoprotein exhibits nucleotide splaying and increased water influx into the RNA-binding pocket’. Journal: Chemical Biology & Drug Design (Wiley Interscience) Chem Biol Drug Des. 2019 Apr;93(4):544-555
AUTHOR(S):
Omotuyi, I. Olaposi; Nash, Oyekanmi; Safronetz, David; Ojo, A. Ayodeji; Ogunwa, H. Tomisin, and Adelakun, S. Niyi.
PUBLICATION TITLE:
27. “Takeda G-protein receptor (TGR)-5 Evolves Classical Active-state Conformational Signatures in Complex with Chromolaena Odorata-derived flavonoid -5,7-dihydroxy-6-4-dimethoxyflavanone”. Current Chemical Biology, 2019, Jan, 13,(10.2174/2212796813666190 102102018)
AUTHOR(S):
Olaposi Omotuyi, Oyekanmi Nash, Okoliko Ukwenya, Enejoh Ojochenemi, Hamada Tsuyoshi, Damilohun Samuel Metibemu
PUBLICATION TITLE:
28. “Genomic History of the Katahdin Hair Sheep” Small Ruminant Research, 2018 (Ref: RUMIN_2018_649)
AUTHOR(S):
Gordon Spangler, Benjamin D Rosen, Eui-Soo Kim, Robert Godfrey, Oyekanmi Nash, David Notter, Joan Burke, James Morgan, Tad Sonstegard, Van Tassell, Curtis P
PUBLICATION TITLE:
29. Chromolaena odorata Flavonoids Attenuate Experimental Nephropathy: Involvement of Pro-inflammatory Gene Downregulation. Journal: Toxicology Reports (Elsevier) Reference: TOXREP_2018_567
AUTHOR(S):
Olaposi Idowu Omotuyi, Oyekanmi Nash, Ojochenemi Aladi Enejoh, Eunice Iyanuoluwa Oribamise, Niyi Samuel Adelakun.
PUBLICATION TITLE:
30. “A metagenomic approach to the characterization of the microbiomes of sickle cell disease-associated leg ulcers” PLOS ONE (PONE-D-18-11020)
AUTHOR(S):
Deborah Fasesan, Jessica Holmes, Jenny Drnevich, Ayodele Ogunkeyede, Gladys Falusi, Victor Jongeneel Oyekanmi Nash .
PUBLICATION TITLE:
31. Geranylnaringenin (CG902) inhibits constitutive and inducible STAT3 activation through the activation of SHP-2 tyrosine phosphatase. Biochem Pharmacol. 2017 Jun 28. pii: S0006-2952(17)30455-0
AUTHOR(S):
Jin Y, Yoon YJ, Jeon YJ, Choi J, Lee YJ, Lee J, Choi S, Nash O, Han DC, Kwon BM.
PUBLICATION TITLE:
32. Signatures of Selection for Environmental Adaptation and Zebu × Taurine Hybrid Fitness in East African Shorthorn Zebu. Front Genet. 2017 Jun 8;8:68. doi: 10.3389/fgene.2017.00068. eCollection 2017
AUTHOR(S):
Bahbahani H, Tijjani A, Mukasa C, Wragg D, Almathen F, Nash O, Akpa GN, Mbole-Kariuki M, Malla S, Woolhouse M, Sonstegard T, Van Tassell C, Blythe M, Huson H, Hanotte O.
PUBLICATION TITLE:
33. Development of Bioinformatics Infrastructure for Genomics Research in H3Africa. Glob Heart. 2017 Mar 13. pii: S2211-8160(17)30005-4
AUTHOR(S):
Mulder NJ, Adebiyi E, Adebiyi M, Adeyemi S, Ahmed A, Ahmed R, Akanle B, Alibi M, Armstrong DL, Aron S, Ashano E, Baichoo S, Benkahla A, Brown DK, Chimusa ER, Fadlelmola FM, Falola D, Fatumo S, Ghedira K, Ghouila A, Hazelhurst S, Isewon I, Jung S, Kassim SK, Kayondo JK, Mbiyavanga M, Meintjes A, Mohammed S, Mosaku A, Moussa A, Muhammd M, Mungloo-Dilmohamud Z, Nashiru O, Odia T, Okafor A, Oladipo O, Osamor V, Oyelade J, Sadki K, Salifu SP, Soyemi J, Panji S, Radouani F, Souiai O, Tastan Bishop Ö; H3ABioNet Consortium, as members of the H3Africa Consortium..
PUBLICATION TITLE:
34. Artocarpus altilis CG-901 alters critical nodes in the JH1-kinase domain of Janus kinase 2 affecting upstream JAK/STAT3 signaling. J Mol Model. 2015 Nov;21(11):280
AUTHOR(S):
Nash O, Omotuyi O, Lee J, Kwon BM, Ogbadu L.
PUBLICATION TITLE:
35. Artocarpus altilis (Parkinson) Fosberg Extracts and Geranyl Dihydrochalcone Inhibit STAT3 Activity in Prostate Cancer DU145 Cells. Phytother Res. 2015 May;29(5):749-56
AUTHOR(S):
Jeon YJ, Jung SN, Chang H, Yun J, Lee CW, Lee J, Choi S, Nash O, Han DC, Kwon BM
PUBLICATION TITLE:
36. Evaluative profiling of arsenic sensing and regulatory Systems in the Human Microbiome Project Genomes. Microbiology Insights. 2014 Nov 11;7:25-34
AUTHOR(S):
Raphael D. Isokpehi, Udensi K. Udensi, Shaneka S. Simmons, Antia E. Cain, Samson A. Olafinsae, Atinuke O. Hassan, Zainab A. Kashim, Ojochenemi A. Enejoh, Deborah E. Fasesan, and Oyekanmi Nashiru.
PUBLICATION TITLE:
37. Inhibition of the calcineurin pathway by two tannins, chebulagic acid and chebulanin, isolated from Harrisonia abyssinica Oliv. J Microbiol Biotechnol. (2014), 24(10), 1389-1393
AUTHOR(S):
Lee WJ, Moon JS, Kim SI, Kim YT, Nash O, Bahn YS, Kim SU (2014).
PUBLICATION TITLE:
38. Enabling the genomic revolution in Africa. Science 20 June 2014: Vol. 344 no. 6190 pp. 1346-1348
AUTHOR(S):
H3Africa Consortium (2014)
PUBLICATION TITLE:
39. Evaluation of the Comparative Efficacy and Safety of Artemether-Lumefantrine, Artesunate-Amodiaquine and Artesunate-Amodiaquine-Chlorpheniramine (Artemoclo) for the Treatment of Acute Uncomplicated Malaria in Nigerian Children . Med. Princ. Pract. Med Princ Pract. 2014;23(3):204-11
AUTHOR(S):
C.O. Falade H.O. Dada-Adegbola O.O. Ogunkunle M.C. Oguike O. Nash and O.G. Ademowo (2014)
PUBLICATION TITLE:
40. H3ABioNet, a Sustainable Pan-African Bioinformatics Network for Human Heredity and Health in Africa. Genome Res. 2016 Feb;26(2):271-7
AUTHOR(S):
Nicola J. Mulder*1, Ezekiel Adebiyi2, Raouf Alami 3, Alia Benkahla4, James Brandful5, Seydou Doumbia6, Dean Everett7, Faisal M. Fadlelmola8, Fatima Gaboun9, Simani Gaseitsiwe10, Hassan Ghazal11, Scott Hazelhurst12, Azeddine Ibrahimi13, Winston Hide14, Yasmina Jaufeerally Fakim15, C. Victor Jongeneel16, Fourie Joubert17, Samar Kassim18 Jonathan Kayondo19, Judit Kumuthini20, Sylvester Lyantagaye21, Julie Makani22, Ahmed Mansour Alzohairy23, Daniel Masiga24, Ahmed Moussa25, Oyekanmi Nash26, Odile Ouwe Missi Oukem-Boyer27, Ellis Owusu-Dabo28, Hugh Patterton29, Fouzia Radouani30, Khalid Sadki31, Fouad Seghrouchni32, Özlem Tastan Bishop33, Nicki Tiffin34, Nzovu Ulenga35, and the H3ABioNet Consortium#, as members of the H3Africa Consortium.
PUBLICATION TITLE:
41. Computational Biology and Bioinformatics in Nigeria. PLoS Comput Biol. 2014 Apr 24;10(4):e100351
AUTHOR(S):
Segun A. Fatumo Moses P. Adoga, Opeolu O. Ojo, Olugbenga Oluwagbemi, Tolulope Adeoye Itunuoluwa Ewejobi, Marion Adebiyi, Ezekiel Adebiyi, Clement Bewaji, and Oyekanmi Nashiru (2014)
PUBLICATION TITLE:
42. Developmental Regulation of Genes Encoding Universal Stress Proteins in Schistosoma mansoni. Gene Regul Syst Bio. 2011;5:61-74.
AUTHOR(S):
Isokpehi RD, Mahmud O, Mbah AN, Simmons SS, Avelar L, Rajnarayanan RV, Udensi UK, Ayensu WK, Cohly HH, Brown SD, Dates CR, Hentz SD, Hughes SJ, Smith-McInnis DR, Patterson CO, Sims JN, Turner KT, Williams BS, Johnson MO, Adubi T, Mbuh JV, Anumudu CI, Adeoye GO, Thomas BN, Nashiru O, Oliveira G
PUBLICATION TITLE:
43. Blood banking in a malaria-endemic area: evaluating the problem posed by malarial parasitaemias. Ann Trop Med Parasitol. 2009 Jul;103(5):383-92.
AUTHOR(S):
Falade CO, Nash O, Akingbola TS, Michael OS, Olojede F, Ademowo OG.
PUBLICATION TITLE:
44. “Phylogenetics and Pathogenesis of Early Avian Influenza (H5N1), Nigeria. Emerging Infectious Diseases, 2008 14 (11): 1753-1755
AUTHOR(S):
Comfort O. Aiki-Raji, Patricia V. Aguilar, Oyekanmi Nash, Chrisopher A.O. Adeyefa,Festus D. Adu, David Swayne, and Christopher Basler
PUBLICATION TITLE:
45. Building Bioinformatics Capacity in West Africa. African J. Med. And Medical Sci., 36:15-18
AUTHOR(S):
Oyekanmi Nashiru, Chuong Huynh, Raphael Isokpehi, Jessica Kissinger, Olufunso Olorunsogo (2007)
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